Aprepitant
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INDICATIONS AND USAGE（适应症）
EMEND® for oral suspension, in combination with other antiemetic agents, is indicated in patients 6 months of age and older for the prevention of:
acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy (HEC) including high-dose cisplatin.
nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy (MEC).
EMEND® capsules, in combination with other antiemetic agents, is indicated in patients 12 years of age and older for the prevention of:
acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy (HEC) including high-dose cisplatin.
nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy (MEC).
DOSAGE（服用剂量）
Adults and Pediatric Patients 12 Years of Age and Older
The recommended oral dosage of EMEND capsules, dexamethasone, and a 5-HT3 antagonist in adults and pediatric patients 12 years of age and older who can swallow oral capsules, for the prevention of nausea and vomiting associated with administration of HEC or MEC. For patients who cannot swallow oral capsules, EMEND for oral suspension can be used instead of EMEND capsules.
Pediatric Patients 6 Months to less than 12 Years of Age or Pediatric and Adult Patients Unable to Swallow Capsules
The recommended dose of EMEND for oral suspension to be administered with a 5-HT3 antagonist, with or without a corticosteroid, for the prevention of nausea and vomiting associated with administration of HEC or MEC. Dosing of EMEND for oral suspension is based on weight, to a maximum of 125 mg on Day 1 and 80 mg on Days 2 and 3. Dosing in pediatric patients less than 6 kg is not recommended.
ADVERSE REACTIONS（不良反应）
Fatigue
Diarrhea
Asthenia
Dyspepsia
Abdominal pain
Hiccups
White blood cell count decreased
Dehydration
Alanine aminotransferase increased
For full information, please refer to:
https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/696f9e80-9cae-403b-de9e-078343ce4713/spl-doc?hl=Emend
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